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Latest News & Announcements

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April 2026

A unifying theory of brain signaling and its possible role in acquired chronic disease

Acquired chronic disease is a significant, growing problem. Research has sought patient abnormalities that drugs can target, but to date, these have only provided equivocal symptom relief and no cures. However, as individual neuronal signals cannot be measured, the role of the brain in such...

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September 2021

Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multi-symptom disease with widespread evidence of disrupted systems. The authors hypothesize that it is caused by the upregulation of the corticotropin-releasing factor receptor type 2 (CRFR2) in the raphé nuclei and limbic...

29

August 2019

Cortene to Move Forward on New Drug for Chronic Fatigue Syndrome (ME/CFS)

In February of last year, Health Rising announced an unusual event was going to take place: a small drug company named Cortene was going to trial a new drug for chronic fatigue syndrome (ME/CFS). Cortene’s trial was unique in a number of ways. For one, it involved ME/CFS – a disease which...

14

July 2018

The Cortene Chronic Fatigue Syndrome (ME/CFS) Drug Trial Begins

Since February, Health Rising has described the development of a new drug produced for chronic fatigue syndrome (ME/CFS) by a small pharmaceutical company named Cortene in three blogs: The Cortene Way: New Drug to Be Trialed in Chronic Fatigue Syndrome (ME/CFS) Soon – Pt. I Cortene II: A New Drug...

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March 2018

[Part III] A New Drug for Chronic Fatigue Syndrome (ME/CFS): The Clinical Trial

An Exploratory Drug Trial For ME/CFS In the next month or so, Cortene, a small drug development company, will do a very unusual thing – trial a new drug in chronic fatigue syndrome (ME/CFS). The first two parts of the series on this new drug covered how ME/CFS came to the attention of Cortene,...

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February 2018

[Part II] A New Drug & A New Hypothesis For Chronic Fatigue Syndrome (ME/CFS)

Part 1 introduced how Cortene became involved in chronic fatigue syndrome (ME/CFS), and introduced its hypothesis that a maladaptation within the limbic system, which shapes our response to stress, may underlie ME/CFS. The Cortene Way: New Drug to Be Trialed in Chronic Fatigue Syndrome (ME/CFS)...